Endocrine Abstracts

Introduction: Since there is no completely effective therapy available for malignant phaeochromocytomas (PCCs) and paragangliomas, we have been investigating novel targeted therapies utilising one more benign (MPC) and one more malignant (MTT) PCC cell line. We have previously shown that the IGF1-receptor-inhibitor NVP-AEW541 led to compensatory ERK and mTORC1 up-regulation at suboptimal doses and that the dual PI3K/mTORC1-inhibitor NVP-BEZ235 also resulted in compensatory ERK...

Background: Cushing disease CD is a rare disorder, caused by an (ACTH) producing tumor. Transsphenoidal pituitary surgery (TSS) remains the treatment of choice for CD. Fewer information is available on the long-term outcome in the group of patients harboring ACTH-secreting adenoma. The aims of this study were to analyze our 20-year experience with surgical treatment in Cushing’s disease and to examine whether remission rate is related with size tumors.<p class="abstex...

Aim: To study the results of transsphenoidal surgery in our Neuroendocrinology Unit in last 10 years.Methods: We reviewed all patients operated in our hospital and followed in our Neuroendocrinology Unit in the last 10 years. We excluded patients with previous surgery or irradiation on this area. We obtained data about type and size of tumor, previous hormonal deficit, local symptoms,complications of surgery and the status after this (remission, persiste...

Introduction: The recombinant GH receptor antagonist pegvisomant (PGV) is actually used for the treatment of acromegaly when surgery and medical therapy with somatostatin analogues (SSA) have failed. Long term safety and effectiveness need to be evaluated.Material and methods: Retrospective analysis of clinical data from all patients treated with pegvisomant in a pituitary disorders unit.Results: Thirteen patients are being treated...

Background: High prevalence of hypovitaminosis D in diabetic patients has been reported and has been associated with microvascular complications and insulin treatment in type 2 diabetic patients.Methods: Observational study in 92 inhospital patients with different types of diabetes. We analyzed the relationship between serum 25-hydroxyvitamin D (25-OHD) concentration and the clinical features associated with diabetes.Results: Of 36...

Objective: Evaluate the markers of oxidative stress and antioxidants status in patients with gestational diabetes (GD).Material and methods: We performed a nested case-control study within a sample of a total of 126 pregnant women between the 24 and 29 weeks. Of the 126 women studied we compared 63 with GD and 63 control pregnant women. Both groups were analyzed for demographic data, perinatal and obstetrics results and the levels of the markers oxidativ...

Objective: Evaluate the proinflammatory and anti-antinflamatory adipokines in patients with gestational diabetes (GD).Material and methods: We performed a nested case-control study within a sample of a total of 126 pregnant women between the 24 and 29 weeks. Of the 126 women studied we compared 63 with GD and 63 control pregnant women. Both groups were analyzed for demographic data, perinatal and obstetrics results and the plasma levels of the tumor necr...

BACKGROUND: Antiangiogenic effects have been demonstrated with currently available somatostatin analogues. The mechanism remains unclear, although some studies suggest inhibition of the pro-angiogenic tumour vascular endothelial growth factor (VEGF) production.OBJECTIVE: To determine whether pre-operative Lanreotide (LAN) in patients with acromegaly influences circulating VEGF.PATIENTS AND METHODS: Serum samples from six acromegal...

Introduction: There is solid epidemiologic evidence linking psoriasis and psoriatic arthritis (PsA) to cardiovascular risk factors and an increased risk for developing cardiovascular diseases. Despite this, dietetic advice is not routinely performed in clinical practice in patients with inflammatory arthropathies and the potential effect of diet on metabolic profile and inflammatory activity is few studied in these patients. This research aims to describe dietetic habits of a ...

Introduction: The T-Coach® telephone support program for patients with type 2 diabetes (DM2) treated with insulin glargine 300 u/ml, facilitates dose adjustments of basal insulin therapy through regular telephone consultations and offers diabetes education in order to improve empowerment of the patient. Objective: To assess the usefulness of the T-Coach® program in metabolic control and degree of satisfaction in patients with T2DM.Patients and ...